Table 1.
Baseline characteristics of connective tissue disease patients in the two cohorts combined.
| N (%) | Age (Years) | Echo-Derived PASP (mmHg) | RHC-Derived PASP (mmHg) | PVR (WU) | Cardiac Index | RAP (mmHg) | NT-pro-BNP (pg/mL) | 6mWD (m) | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Underlying disease | SSc | 58 (84) | 61.45 ± 11.68 | 65.72 ± 17.01 | 59.02 ± 16.23 | 6.41 ± 2.96 (n = 55) |
2.50 ± 0.63 | 6.62 ± 3.52 | 1848.69 ± 2643.41 (n = 45) |
357.74 ± 124.69 (n = 43) |
| MCTD | 6 (9) | 63.17 ± 8.75 | 61.67 ± 27.66 | 60.50 ± 13.66 | 6.35 ± 3.39 | 2.40 ± 2.4 | 8.17 ± 3.54 | 1493.67 ± 1540.89 (n = 3) |
378.0 ± 75.78 | |
| SLE | 5 (7) | 49.00 ± 13.3 | 64.20 ± 19.38 | 73.40 ± 17.57 | 7.05 ± 2.79 (n = 4) |
2.42 ± 0.10 | 9.0 ± 4.53 | 4142.75 ± 5678.68 (n = 4) |
290.0 ± 262.11 (n = 3) |
|
| Gender | female | 59 (86) | 61.64 ± 11.95 | 63.58 ± 17.82 | 59.31 ± 16.81 | 6.42 ± 3.12 (n = 57) |
2.51 ± 0.58 | 6.82 ± 3.71 | 2129.72 ± 3053.44 (n = 46) |
351.94 ± 132.31 (n = 48) |
| male | 10 (14) | 55.10 ± 10.47 | 75.2 ± 16.14 | 65.4 ± 12.57 | 6.55 ± 1.24 (n = 8) |
2.32 ± 0.59 | 7.6 ± 2.99 | 1046.0 ± 814.72 (n = 4) |
407.0 ± 19.90 (n = 4) |
|
| NYHA stage | I | 0 | - | - | - | - | - | - | - | - |
| II | 22 (32) | 56.91 ± 12.01 | 55.45 ± 13.43 * | 56.77 ± 13.49 | 5.55 ± 1.7 | 2.56 ± 0.33 | 6.18 ± 2.36 | 723.76 ± 1013.77 (n = 17) |
442.6 ± 69.80 **
(n = 20) |
|
| III | 37 (54) | 62.38 ± 11.85 | 65.57 ± 16.94 * | 57.72 ± 16.31 | 5.95 ± 2.79 (n = 34) |
2.57 ± 0.66 | 6.49 ± 3.62 | 1657.48 ± 2004.25 (n = 27) |
348.62 ± 65.98 **
(n = 26) |
|
| IV | 10 (14) | 62.80 ± 10.94 | 85.7 ± 12.92 * | 76.8 ± 12.88 # |
10.49 ± 2.89 #
(n = 9) |
2.00 ± 0.51 # | 10.2 ± 4.37 # |
5897.37 ± 4717.60 #
(n = 8) |
100.83 ± 135.44 **
(n = 6) |
|
| Total cohort | 69 (100) | 60.70 ± 11.90 | 65.26 ± 17.95 | 60.19 ± 16.33 | 6.44 ± 2.95 | 2.48 ± 0.59 | 6.93 ± 3.61 | 2004.67 ± 2900.68 | 356.17 ± 127.96 | |
Continuous values are presented as mean ± SD. (SSc: Systemic Sclerosis, MCTD: Mixed Connective Tissue Disease, SLE: Systemic Lupus Erythematosus, NYHA: New York Heart Association, PASP: Pulmonary Artery Systolic Pressure, RHC: Right Heart Catheterization, PVR: Pulmonary Artery Resistance, RAP: Right Atrial Pressure, NT-pro-BNP: N-terminal pro Brain Natriuretic Peptide, 6mWD: 6 min Walking Distance).* p = 0.052 for NYHAII vs NYHA III, p < 0.05 for NYHA II vs NYHA IV and NYHA III vs NYHA IV; # p < 0.05 for NYHA II vs NYHA IV and NYHA III vs NYHA IV; ** p < 0.001 for all comparisons.