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. 2020 Feb 7;8(2):26. doi: 10.3390/biomedicines8020026

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Comparison of dynamic C-peptide secretion profiles (left panels) and areas under the curve (AUCs, right panels) of human PIs derived from different donors and HLSC-ILS. (A) Single pulse of glucose (HG; 28 mM) and potassium (KCl; 50 mM) protocol; (B) two consecutive pulses of glucose (HG; 17 mM); (C) ramp of glucose concentration (3–30 mM); (D) constant high-glucose concentration (HG = 17 mM) protocol. Basal concentration of glucose (LG) for all protocols was 3 mM. Results are presented as mean ± SD of PIs from healthy (n = 3), obese (n = 2), T2DM (n = 3) and HLSC-ILS (n = 3–5). ANOVA with Turkey’s multi-comparison test was performed; * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.