Figure 1.
Bone morphogenetic protein 5 (BMP5) transcription level in different types of cancer derived from the ONCOMINE and Gene Expression across Normal and Tumor Tissue (GENT) databases. (A) This graphic was generated from the ONCOMINE database, indicating the number of datasets with statistically significant (p < 0.01) mRNA overexpression (red) or down-regulation (blue) of BMP5 (different types of cancer vs. corresponding normal tissue). The threshold was designed with the following parameters: p-value of 1 × 10−4, fold change of 2, and gene ranking of 10%. (B) BMP5 mRNA expression pattern in normal and tumor tissues. BMP5 mRNA expression in various types of cancer was obtained from the GENT database. X-axis exhibits log2 fold change values of BMP5 expression whereas, Y-axis shows the types of tissues BMP5 were expressed. Boxes represent the median and the 25th, and 75th percentiles dots represent outliers. Red boxes represent tumor tissues; blue boxes represent normal tissues. Red and blue dashed lines represent the average value of all tumor and normal tissues, respectively.