Table 7.
Nonsynonymous mutations associated with sulphadoxine resistance in dihydrofolate reductase (Pvdhfr) gene and nonsynonymous mutations associated with pyrimethamine resistance in dihydropteroate synthetase (Pvdhps) gene.
| Genes | Nucleotide Position | Nucleotide Change | Amino acid Position | Amino Acid Change |
|---|---|---|---|---|
| Pvdhfr | 171–173 | TTC -> TTG, TTA, CTC | 57 | (F) Phenylalanine -> (L) Leucine |
| (g.173C>G, g.173C>G, g.173C>A, g.171T>C) | (F57L) | |||
| 171–173 | TTC -> ATA | 57 | (F) Phenylalanine -> (I) Isoleucine | |
| (g.171T>A and 173C>A) | (F57B) | |||
| 172–174 | AGC -> AGG, AGA | 58 | (S) Serine -> (R) Arginine | |
| (g.174C>G, g.174C>G) | (S58R) | |||
| 183–185 | ACG ->ATG | 61 | (T) Threonine -> (M) Methionine | |
| (g.184C>T) | (T61M) | |||
| 351–353 | AGC -> ACC | 117 | (S) Serine -> (T) Threonine | |
| (g.352G>C) | (S117M) | |||
| 351–353 | AGC -> AAC | 117 | (S) Serine -> (N) Asparagine | |
| (g.352G>A) | (S117N) | |||
| Pvdhps | 1149–1151 | GCC -> GGC | 383 | (A) Alanine -> (G) Glycine |
| (g.1150C>G) | (A383G) | |||
| 1659–1661 | GCC -> GGC | 553 | (A) Alanine -> (G) Glycine | |
| (g.1660C>G) | (A553G) |
Pvdhfr = the dihydrofolate reductase gene; Pvdhps = the dihydropteroate synthetase gene.