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NS-1 neurite outgrowth is inhibited by aggrecan in a dose-dependent manner. Dose response curve for all concentrations of aggrecan analyzed (A). Neurite outgrowth at 125 ng/mL (B), 250 ng/mL (C) and 500 ng/mL (D) NGF in the presence of 0, 37.5, 150, or 300 µg.mL aggrecan. * p < 0.05, ** p < 0.01, compared to 0 µg/mL condition (Bonferonni post-hoc analysis).
