Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 12;9(2):29. doi: 10.3390/biology9020029

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Effect of aggrecan post-translational modifications on neurite outgrowth. (A) In the presence of intact aggrecan there is reduced maximal growth when compared to growth on collagen, likely due to the activation of CS receptors and receptors for N-glycans. (B) Removal of CS abolishes some inhibition, but there is no apparent effect of further removal of KS (C), suggesting no KS-receptor interaction. Removal of N-glycans following CS and KS removal abolishes inhibition, suggesting an interaction of N-glycans with a receptor on the growth cone.