Table 3.
Interaction between N. alba extracts and cisplatin on the A2780 and A2780cisR cancer cell lines. Fa is the fraction affected by dose; CI is the combination index.
| Drug (µg/mL) | A2780 * | A2780cisR * | |||
|---|---|---|---|---|---|
| Leaf | CisPt | Fa | CI | Fa | CI |
| 1000 | 100 | 0.03 | 4.85 | 0.12 | 1.20 |
| 500 | 50 | 0.01 | 1.03 | 0.10 | 0.44 |
| 200 | 20 | 0.04 | 1.22 | 0.06 | 0.08 |
| 100 | 10 | 0.02 | 0.35 | 0.07 | 0.05 |
| 10 | 1 | 0.70 | 2.07 | 0.60 | 0.57 |
| Root | CisPt | Fa | CI | Fa | CI |
| 1000 | 100 | 0.10 | 12.59 | 0.25 | 2.81 |
| 500 | 50 | 0.12 | 7.64 | 0.32 | 2.28 |
| 200 | 20 | 0.09 | 2.25 | 0.17 | 0.30 |
| 100 | 10 | 0.12 | 1.52 | 0.26 | 0.30 |
| 10 | 1 | 0.69 | 2.25 | 0.89 | 10.03 |
* A2780—ovarian tumor cells; A2780cisR—ovarian tumor cisplatin-resistant cells. Cisplatin = CisPt