Table 2.
Standard coagulation parameters after addition of tigecycline in increasing concentrations (n = 14).
| Tigecycline Concentration (µg/mL) |
Baseline | 0.106 | 1.06 | 10.6 | 106 |
|---|---|---|---|---|---|
| aPTT (s) | 29.38 ± 2.26 | 29.38 ± 2.10 | 29.62 ± 2.33 | 29.69 ± 2.56 | 38.92 ± 5.22 1 |
| Quick (%) | 91.46 ± 7.32 | 91.00 ± 6.40 | 89.46 ± 7.43 | 90.85 ± 8.29 | 85.00 ± 5.92 |
| International Normalized Ratio | 1.05 ± 0.07 | 1.05 ± 0.05 | 1.07 ± 0.06 | 1.05 ± 0.07 | 1.09 ± 0.06 |
| Fibrinogen by Clauss (mg/dL) | 266.69 ± 60.79 | 260.10 ± 61.23 | 258.20 ± 55.29 | 258.20 ± 49.57 | 258.10 ± 59.75 |
| Fibrinogen antigen (mg/dL) | 258.23 ± 34.47 | 245.20 ± 33.19 | 244.30 ± 33.73 | 241.50 ± 39.00 | 247.80 ± 34.76 |
| Thrombin time (s) | 20.38 ± 1.76 | 19.92 ± 1.80 | 20.15 ± 1.73 | 19.77 ± 1.88 | 20.38 ± 1.98 |
| Batroxobin time (s) | 16.38 ± 0.51 | 16.31 ± 0.75 | 16.23 ± 0.60 | 16.15 ± 0.55 | 16.23 ± 0.44 |
| F. XIII (%) | 108.44 ± 13.93 | 114.30 ± 16.06 | 113.70 ± 17.85 | 114.20 ± 15.85 | 112.20 ± 16.15 |
| F. XIII, immunologic (%) | 103.18 ± 9.23 | 106.10 ± 10.97 | 105.50 ± 10.42 | 105.90 ± 8.93 | 105.60 ± 9.12 |
1p < 0.0001. aPTT reflects activated partial thromboplastin time, F. XIII reflects coagulation factor XIII, F. XIII, immunologic reflects coagulation factor XIII as assessed immunologically. Data are presented as means ± standard deviations; Statistically significant differences between groups were tested by One-Way ANOVA or Kruskal–Wallis-Test. Post-hoc multiple comparison of significant results were tested by Dunnet’s multiple comparison test.