Table 3.
Rotational thromboelastometry after addition of tigecycline in increasing concentrations in blood samples of healthy volunteers (n = 14).
| Tigecycline Concentration (µg/mL) |
Baseline | 0.106 | 1.06 | 10.6 | 106 |
|---|---|---|---|---|---|
| INTEM | |||||
| Clotting Time (s) | 189.3 ± 19.4 | 194 ± 39 | 194 ± 27 | 182 ± 54 | 192 ± 22 |
| Maximum Clot Firmness (mm) | 56.5 ± 4.3 | 58 ± 5 | 57 ± 5 | 57 ± 5 | 58 ± 5 |
| Maximum Lysis (%) | 11.0 ± 2.2 | 10 ± 2 | 9 ± 2 | 10 ± 2 | 11 ± 2 |
| EXTEM | |||||
| Clotting Time (s) | 75.0 ± 9.2 | 76 ± 10 | 72 ± 6 | 72 ± 11 | 79 ± 12 |
| Maximum Clot Firmness (mm) | 61.2 ± 5.6 | 61 ± 6 | 59 ± 6 | 60 ± 6 | 61 ± 7 |
| Maximum Lysis (%) | 9.2 ± 1.9 | 9 ± 2 | 9 ± 2 | 9 ± 2 | 9 ± 3 |
| FIBTEM | |||||
| Clotting Time (s) | 63.8 ± 16.3 | 71 ± 7 | 68 ± 17 | 67 ± 10 | 72 ± 9 |
| Maximum Clot Firmness (mm) | 13.9 ± 5.3 | 11 ± 4 | 13 ± 2 | 15 ± 6 | 12 ± 2 |
| Maximum Lysis (%) | 3.6 ± 5.4 | 2 ± 4 | 4 ± 3 | 9 ± 11 | 2 ± 3 |
INTEM reflects intrinsically activated test using ellagic acid, EXTEM reflects extrinsically activated assay with tissue factor, FIBTEM reflects extrinsically activated assay with tissue factor and the platelet inhibitor cytochalasin D. Data are presented as means ± standard deviations.