Table 1.
Cytotoxic activity of 5-(Carbamoylmethylene)-oxazolidin-2-ones in comparison to that of doxorubicin a.
| Compound | HeLa | MCF-7 | MCF-10A | |||
|---|---|---|---|---|---|---|
| IC50 | 95% Confidence Interval | IC50 | 95% Confidence Interval | IC50 | 95% Confidence Interval | |
| DOX | 3.61 | 3.02 to 4.32 | 4.04 | 3.25 to 5.03 | 31.75 | 25.16 to 40.08 |
| OA | 52.53 | 42.81 to 64.45 | 56.90 | 50.43 to 69.18 | 414.3 | 336.3 to 510.5 |
| OB | 98.21 | 81.46 to 118,0 | 121.8 | 107.0 to 139.7 | 469.6 | 378.9 to 582.1 |
| OC | 99.47 | 88.42 to 111.9 | 163.3 | 135.2 to197.2 | 494.5 | 406.2 to 602.2 |
| OD | 154.5 | 136.4 to 175.1 | 338.4 | 284.8 to 402.0 | 506.4 | 410.1 to 625.4 |
| OE | 129.3 | 114.0 to 146.0 | 303.7 | 258.3 to 357.0 | 978.2 | 718.3 to 1332 |
| OF | 159.4 | 138.5 to 183.6 | 409.3 | 348.8 to 480.3 | 718.4 | 506.6 to 1019 |
| OG | 134.4 | 113.5 to 159.2 | 344.9 | 290.4 409.6 | 677.1 | 530.3 to 864.5 |
| OH | 54.21 | 42.67 to 68.88 | 92.91 | 78.99 to 109.3 | 318.8 | 263.1 to 386.3 |
| OI | 31.10 | 26.29 to36.80 | 17.66 | 15.67 to 19.91 | 351.3 | 288.4 to 427.8 |
a Data are presented as IC50 values (µM) and 95% confidence intervals obtained by nonlinear regression analysis of three independent experiments.