Table 3.
Anti‐HCV activity (IC50), cytotoxicity (CC50) and selectivity index (SI) of G. uralensis‐ and other Glycyrrhiza spp‐derived compounds
| Sample | IC50 (µg/mL) | CC50 (µg/mL) | SI |
|---|---|---|---|
| Triterpenoids | |||
| Glycyrrhizin | 180 | 560 | 3.1 |
| Glycyrrhizic acid monoammonium | 320 | 690 | 2.2 |
| Glycyrrhetic acid 3‐O‐glucuronide | >30b | >30 | na |
| Glycyrrhetinic acid | 40.0 | 77.4 | 1.9 |
| Licorice‐saponin G2 | >30b | >30 | na |
| Licorice‐saponin H2 | >30b | >30 | na |
| Coumarins | |||
| Glycycoumarin (isolated) | 8.8 | 69.0 | 7.8 |
| Glycyrin (isolated) | 7.2 | 25.0 | 3.5 |
| Glycyrol (isolated) | 4.6 | 35.5 | 7.7 |
| Flavonoids | |||
| Flavanones | |||
| Liquiritin | 75.0 | 570 | 7.6 |
| Liquiritigenin | 16.4 | 125 | 7.6 |
| Chalcones | |||
| Isoliquiritigenin | 3.7 | 11.0 | 3.0 |
| Licochalcone Aa | 2.5 | 20.0 | 8.0 |
| Isoflavan | |||
| Glabridina | 6.2 | 22.7 | 3.7 |
a
Not detected in G. uralensis 34.
b
No detectable HCV inhibition at 30 μg/mL. na, not applicable.