Table 4.
Mode‐of‐action analysis of anti‐HCV activities of G. uralensis‐ and other Glycyrrhiza spp.‐derived compounds
| Compound | Conc. (mg/mL)a | Anti‐HCV activity (% inhibition) | ||
|---|---|---|---|---|
| During‡ | After‡ | During & afterb | ||
| Chloroform partition | 30 | 28.6 | 100 | 100 |
| Glycycoumarin | 20 | 16.7 | 100 | 100 |
| Glycyrin | 15 | 18.4 | 98.3 | 99.6 |
| Glycyrol | 10 | 21.3 | 100 | 100 |
| Liquiritigenin | 30 | 15.5 | 90.0 | 87.2 |
| Isoliquiritigenin | 8 | 14.1 | 91.0 | 82.5 |
| Licochalcone A | 5 | 0 | 94.4 | 93.8 |
| Glabridin | 12 | 0 | 91.0 | 93.8 |
a
The concentrations of each compound used were 2 × IC50.
b
Treatment with the compound was administered only during, only after or both during and after virus inoculation.