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Organization of the enterovirus genome (top) and main functions of nonstructural proteins (bottom). The protein coding region of the enterovirus genome is flanked by the 5′and 3′untranslated region (UTR). A small virus protein (VPg) is covalently linked to the 5′UTR containing the internal ribosome entry site (IRES). The 3′UTR has a poly(A) tail like cellular messenger RNAs.
