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. 2013 Jun 25;34(2):301–339. doi: 10.1002/med.21289

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© 2013 Wiley Periodicals, Inc.

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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Chemical structure and NP‐binding site of nucleozin. (A) Chemical structure of nucleozin (R = H),236 3061 (R = Cl),238 and compound 3 (R = OMe).239 (B) X‐ray structure of the oligomeric complex of compound 3 with influenza virus NP. Six molecules of compound 3 bridge two NP trimers (NP trimer A and NP trimer B) to form a hexamer. [Taken from Gerritz et al.,239 with permission.] Critical interactions made by compound 3 include a hydrogen bond with Ser376 and a π‐stacking interaction with Tyr289.