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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Nat Rev Cancer. 2019 May;19(5):283–288. doi: 10.1038/s41568-019-0128-6

Figure 2. Inheritance of chromosomal versus extrachromosomal DNA.

Figure 2.

(Left panel) During mitosis, chromosomal DNA is evenly split between two daughter cells. (Right panel) Extrachromosomal DNA lacks centromeres and possibly segregates unevenly. As a result, the number of options for distribution of ecDNA between daughter cells equals n+1, where n is the number of ecDNA elements in the parental cell.