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. 2019 Dec 18;9(1):2. doi: 10.3390/pathogens9010002

Figure 1.

Figure 1

Transmissible gastroenteritis virus (TGEV) spike (S) protein domains. The bar in the upper part represents the S protein structure from a reference strain of an enteric TGEV (GenBank accession number AJ271965). The numbers above each bar indicate amino acid positions. S1 and S2 domains are indicated. SP, signal peptide (red); HR, heptad-repeat motifs (purple); TM, transmembrane domain (dark blue). The bars below represent a detail of N-terminus for enteric (C11) and respiratory [porcine respiratory coronavirus (PRCV), Purdue type virus (PTV)] TGEV-derived viruses, as previously defined in [16]. Several motifs are indicated: Antigenic sites C, B, D, and A (green) as previously defined in [9,28]; porcine aminopeptidase N (pAPN) binding domain (orange); Sialic acid (SAc) binding domain (light blue); large deletion (white rectangle); and in frame two amino acid deletion (red). E, enteric; R, respiratory.