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. 2020 Feb 21;9(2):147. doi: 10.3390/pathogens9020147

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Role of TLRs and associated signaling in SLY-negative S. suis strain 89-1591-induced IL-1β production by bmDCs. (A) Percentage of IL-1β production induced 16 h following infection of bmDCs deficient for MyD88, TRIF, TLR2 or TLR4, with regards to wild-type counterparts (normalized to 100%). (B) Percentage of IL-1β production from bmDCs following pretreatment with inhibitors of NF-kB, p38, MEK or JNK and infection with 1 × 10⁶ CFU of strain 89-1591 with regards to vehicle-treated bmDCs (DMSO; normalized to 100%). Data are expressed as mean ± SEM (n = 3). * (p < 0.05) indicates a significant difference with wild-type or vehicle-treated bmDCs.