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SLY-negative S. suis strain 89-1591-induced bmDC IL-1β production is caspase-1, NLRP3 and AIM2 dependent. Percentage of IL-1β secretion by caspase-1- (CASP-1), NLRP3-, AIM2-, NLRP1- or NLRC4-deficient bmDCs after 16 h of infection with 1 × 106 CFU of strain 89-1591 by ELISA, in comparison to wild-type counterparts (normalized to 100%). Data represent the mean ± SEM (n = 3); * (p < 0.05) indicates a significant difference obtained with wild-type bmDCs.
