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IL-1 is required for SLY-negative S. suis strain 89-1591-induced IL-6 and CCL3 production in blood, liver and spleen. Plasma, liver and spleen levels of IL-6 (A) and CCL3 (B) in wild-type (WT) and IL-1R-/- mice 12 h, 48 h and 72 h following infection with 1 × 107 CFU. Data represent the mean ± SEM (n = 3). * (p < 0.05) indicates a significant difference between WT and IL-1R-/- mice.
