Table 1.

Host proteins that interact with capsid and how antivirals preventing this interaction may affect the virus.

Location.	Pathway	Protein	Result	Pro- or Anti- viral	Antiviral treatment could	References
Endoplasmic Reticulum	Vesicular Transport	YKT6 SCFD1 USE1 VAPB STX8 TMEM85 SAR1B	Movement of capsid from site of cleavage to lipid droplets or nucleus	Pro	Prevent capsid storage on lipid droplets, entry into nucleus/nucleolus, prevent particle assembly	[61]
	Signal Peptidase Complex	SPC52 SEC11A SPC53	Cleavage of capsid from flavivirus polyprotein
	ER Stress Response	PARP16 DORGK1 UBXN8 RTN3 SLC33A1	Cell survival or cell death	Anti
Nucleus	Importins	IPO7 IPO9	Targeting of viral capsid to nucleus	Both	Prevent capsid interaction & entry into host nucleus	[19,20,30,36,61]
	LINC Complex	SUN1 SYNE2	Interaction with nuclear membrane			[61]
	NPC	NUP35 NUPL2 TMEM48 POM121	Entry of viral capsid into host nucleus			[61]
	NMD Pathway	PABPC UPF1	Prevent degradation of viral transcripts, increase degradation of host transcripts	Pro	Allow degradation of viral transcripts by host cells	[58]
	Host Transcription	DAXX	Prevent binding of host transcription factors		Prevent changes in host gene transcription	[60]
		Core Histones	Change position of histones			[59]
Nucleolus	p53 regulation	MDM2	p53 induced apoptosis	Anti		[23]
	RNA methylation	NSUN2	Modified methylation of tRNAs, mRNAs, and ncRNAs	Not yet understood	Prevent changes in transcript methylation	[61]
	Ribosome biogenesis	NOL8 NOP16 NOC4L B23 NPM1 nucleolin	Ribosomal stress	Anti		[61]
						[21]
						[56]
	Protein turnover	Jab1	Remove viral capsid protein			[19]
Lipid Metabolism	Lipid droplets	AGPAT6 LPCAT2 AUP1 MBOAT2	Storage of accumulated capsid until particle assembly	Pro	Cause issues with particle formation; formation of VLPS	[61]
	Sphingolipid Metabolism	KDSR TEX2	Initial budding into ER
	Lipid binding	GRAMD1A GRAMD3	Interaction with lipid membrane
	Ceramide Metabolism	SMPD4 CERS2 GBA2	Initial budding into ER

Notes: The table is color coded for easier viewing: ER: blue, nucleus: green, nucleolus: red, and lipid metabolism: orange.