Table 1.

Aurone compounds studied and their observed and predicted antimalarial activities.

Compounds	R	R1	R2	IC50 (μM)	pIC50(obs)	pIC50(pred)	Residual
1	H	OH	OH	94.5	4.024	4.041	-0.017
2	H	OMe	OMe	60.3	4.220	4.306	-0.086
3a	4′-Me	OH	OH	63.4	4.198	4.055	0.143
4	2′-Et	OMe	OMe	21	4.678	4.541	0.137
5	2′-Et	OH	OH	113.5	3.945	4.273	-0.328
6	4′-Et	OH	H	28	4.553	4.43	0.123
7a	4′-tBu	OMe	OMe	13.3	4.876	4.794	0.082
8	4′-Bu	OMe	OMe	11.8	4.928	4.845	0.083
9	4′-Br	OMe	OMe	49.8	4.303	4.334	-0.031
10a	4′-F	OMe	OMe	86.7	4.062	4.392	-0.33
11	4′-OH	OH	H	130	3.886	4.033	-0.147
12	4′-OMe	OMe	OMe	11	4.959	4.697	0.262
13a	4′-Ph	OMe	OMe	234	3.631	4.238	-0.607
14	4′-Py	OMe	OMe	85	4.071	3.95	0.121

^aCompounds in the test set.