Table 4.

Statistical parameters for the validation of CoMFA and CoMSIA/SEA model.

Parameter	Validation Criteria	CoMFA	CoMSIA/SEA
$Q^2$	$Q^2>0.5$	0.501	0.526
r2	r2 > 0.6	0.718	0.765
$\left|r_0^2-r_0^{\text{'}2}\right|$	$\left|r_0^2-r_0^{\text{'}2}\right|<0.3$	0.21	0.057
k	0.85 < k < 1.15	1.1	1.09
$\frac{r^2-r_0^2}{r^2}$	$\frac{r^2-r_0^2}{r^2}<0.1$	0.02	0
K′	0.85 < k’<1.15	0.84	0.87
$\frac{r^2-r_0^{\text{'}2}}{r^2}$	$\frac{r^2-r_0^2}{r^2}<0.1$	0.31	0.06
$r_m^2$	$r_m^2>0.5$	0.63	0.765
$r_m^{\text{'}2}$	$r_m^{\text{'}2}>0.5$	0.37	0.582