Table 2.
Characteristics of clusters identified by SPM-12 using small volume correction to spatially constrain multiple comparisons correction in pre-defined regions.
| Analysis | Cluster size | x | y | z | p | Bonferroni critical α | |
|---|---|---|---|---|---|---|---|
| Anterior cingulate | Interaction ND > T1D | 208 | 2 | 38 | 0 | 0.037 | 0.0125 |
| Thalamus | Conjunction | 1325 | 6 | −12 | 4 | 0.002* | 0.0125 |
| Orbitofrontal cortex | Conjunction | 522 | 46 | 40 | −16 | 0.009* | 0.0125 |
Interaction (ND response greater than T1D response) and conjunction analyses (common ND and T1D response). Peak voxel coordinates (x, y, z) given in Montreal Neurological Institute space. T1D: type 1 diabetes; ND: non-diabetic; ROI: region of interest.
*
Significant p value after Bonferroni correction for the number of ROI tests (critical alpha p < 0.0125).