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Time activity curves for 11C-osimertinib in a human subject (subject 4). (a) Total radioactivity concentration in blood and radioactivity concentration for parent radioligand in plasma. Inset shows blood radioactivity concentration during the initial five minutes after injection. Whole brain (b) and regional radioactivity (c). Experimental values for the whole brain and white matter with corresponding fitted curves as obtained by the 1TCM and 2TCM (d).
