Table 1.
Rate constants (K1, k2, k3, k4) and total volume of distribution (VT) for 11C-osimertinib obtained using a two-tissue compartment model.
| Brain region | K1 (mL·cm−3·min−1) | k2 (min−1) | k3 (min−1) | k4 (min−1) | VT (mL·cm−3) |
|---|---|---|---|---|---|
| Caudate nucleus | 0.16 (0.11–0.18) | 0.03 (0.01–0.05) | 0.13 (0.02–0.21) | 0.34 (0.05–1.99) | 15 (11–21) |
| Cerebellum | 0.22 (0.14–0.24) | 0.13 (0.09–0.18) | 0.28 (0.15–0.40) | 0.04 (0.03–0.04) | 13 (10–16) |
| Frontal cortex | 0.21 (0.14–0.23) | 0.09 (0.04–0.28) | 0.27 (0.12–0.58) | 0.08 (0.03–0.24) | 15 (12–22) |
| Insular cortex | 0.21 (0.13–0.30) | 0.33 (0.06–1.62) | 0.49 (0.12–1.62) | 0.03 (0.02–0.05) | 16 (12–23) |
| Limbic cortices | 0.18 (0.12–0.21) | 0.11 (0.05–0.20) | 0.29 (0.16–0.55) | 0.04 (0.03–0.06) | 14 (10–19) |
| Occipital cortex | 0.30 (0.21–0.37) | 0.73 (0.10–1.78) | 0.96 (0.23–1.84) | 0.03 (0.02–0.05) | 16 (13–20) |
| Parietal cortex | 0.23 (0.18–0.27) | 0.18 (0.04–0.56) | 0.41 (0.11–0.87) | 0.05 (0.03–0.08) | 16 (13–22) |
| Putamen | 0.21 (0.14–0.24) | 0.06 (0.02–0.16) | 0.21 (0.06–0.59) | 0.07 (0.04–0.21) | 17 (13–24) |
| Temporal cortex | 0.20 (0.13–0.24) | 0.14 (0.06–0.41) | 0.37 (0.15–0.97) | 0.04 (0.03–0.08) | 16 (12–22) |
| Thalamus | 0.23 (0.14–0.34) | 0.38 (0.03–1.91) | 0.51 (0.14–2.07) | 0.04 (0.02–0.06) | 16 (13–23) |
| Whole brain | 0.17 (0.12-0.19) | 0.08 (0.04-0.14) | 0.19 (0.11-0.29) | 0.04 (0.03-0.07) | 14 (11-18) |
Note: Data are presented as mean and range for seven subjects.