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. 2019 Mar 21;40(4):747–759. doi: 10.1177/0271678X19836118

Figure 4.

Figure 4.

IV injection of Maclpil-silenced M(LPS) (MSM) protected against acute ischemic stroke. (a) Schematic diagram of experimental design. Behavioral training started five days before surgery. Cells were injected immediately after MCAO surgery (Day 0). Mice were euthanized for TTC staining on day 3 after stroke onset. Behavior test and neurological scores were tested from day 3 to day 7. (b) Representative TTC staining and the bar graph show the statistical results of infarct sizes as percentages measured at three days after ischemic stroke. n = 6–8 mice/group. (c) Survival curve from day 0 to day 15 after MCAO. n = 10–12 mice/group. (d) Neurological score from day 3 to day 7, n = 10–12 mice/group. One-way ANOVA, *,** p < 0.05, p < 0.01. (e) The behavioral assessment was conducted by using the pole test, showing the average walking time from the top to the bottom of the vertical pole. n = 10–12 mice/group. *, **, **** p < 0.05, p < 0.01, p < 0.0001. Two-way ANOVA followed by Tukey's multiple comparisons test (within each column).