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Effect of DPM on the ICH-induced pro-inflammatory state in the perihematomal area. Animals were subjected to ICH and treatment with 0.9% saline (vehicle), free dauricine (DRC), empty micelles (PM) or dauricine-loaded micelles (DPM). The sham group was set up by performing craniotomy without blood infusion. At 24 h later, brain tissue was isolated and assayed by ELISA for a IL-6, b IL-1β and c TNF-α, or by Western blot for d, e MMP-9. Values are mean ± SD (n = 3). *P < 0.05
