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. 2020 Apr 20;39:69. doi: 10.1186/s13046-020-01569-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — dPCR analysis of ctDNAs at surgery and from patients bearing metastatic CRC. ctDNAs/tDNA pairs from representative patients (at surgery and metastatic, upper and lower panels, respectively) were assessed by dPCR. Different input DNAs were used in different rows: NTC, no template control; cfDNA, circulating free DNA from healthy donors; ctDNAs and tDNAs, paired tumor and plasma samples from any given patient. Group A patients are arranged top to bottom in order of increasing pathological staging and grading. Yellow, red, blue and green dots depict not amplified, WT, MUT and double-positive dPCR spots, respectively. Red, blue and green dots altogether: cfDNA. Blue and green dots: ctDNA. ctDNA copies per mL are noted