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. 2020 Apr 20;39:69. doi: 10.1186/s13046-020-01569-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Comparison between conventional serum biomarkers and circulating DNA. a Regression analysis of ctDNA dPCR values on the day of surgery paired with serum CEA and Ca19.9 levels assessed in the 15 days prior to surgery. All values are in logarithmic scale. Regression coefficients and p values are shown. ns: nonsignificant. Red dotted lines: CEA and Ca19.9 positivity threshold (4.7 ng/ml and 34 U/ml, respectively). Samples with undetectable ctDNAs are aligned to the Y axis. b A scoring matrix was built to match dPCR positives (any value) and negatives (undetectable) on the one hand vs CEA and Ca19.9 positives and negatives on the other