Figure 3.

Suppression of prostaglandin E2 (PGE₂) in plasma and nevi following single dose of ASA. (A), Experimental design. Human subjects were each given a single 325 mg dose of ASA, and blood and nevus samples were obtained both before (pre) and either 4 (n = 5), 8 (n = 3), or 24 (n = 3) h later. (B), Plasma PGE₂ levels before (open circles) and after (filled circles) aspirin treatment. (C), Average percent reduction in plasma PGE₂ at each time point from (B). Error bars represent SEM. p = 0.09, ANOVA. (D), PGE₂ levels in nevi taken before (open circles) and after (filled circles) ASA treatment. (E), Average percent reduction in nevus PGE₂ at each time point from (D). Error bars represent SEM. p = 0.8, ANOVA. For the ANOVA analyses, the log ratio was first calculated for each subject, and then the log ratios were compared between groups.