Figure 5.

Detection of ASA metabolites in nevi following 1 week of daily ASA exposure. Human subjects were each given ASA daily for one week, and nevi were obtained both before (pre) and after (post) this period. (A), Protocol for 325 mg dosing. (B), Levels of salicylate and salicylurate in nevi in the 325 mg cohort. * p < 0.0001, paired t-test. (C), Protocol for 81 mg dosing. (D), Levels of salicylate and salicylurate in nevi in the 81 mg cohort. * p < 0.01, paired t-test. Salicylurate was detected in nevi of only two subjects from the 81 mg cohort (not shown). Gentisic acid and salicyl acyl glucuronide were not detected in any of the nevi.