Table 1.
Demographic data, SARA, and visual field.
| Gender (Male/Female) | Control | FRDA | p-Value | Spearman Correlation SARA | p-Value Spearman Correlation | Spearman Correlation SARA Follow-Up | p-Value Spearman Correlation Follow-Up | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | Follow-Up | Baseline | Follow-Up | Control Baseline vs. Control Follow-Up * | Control Baseline vs. FRDA Baseline * | Control Follow-up vs. FRDA Follow-Up * | FRDA Baseline vs. FRDA Follow-Up * | |||||
| n = 16 | n = 16 | n = 16 | n = 16 | |||||||||
| (4/4) | (4/4) | (4/4) | (4/4) | |||||||||
| Mean ± SD | ||||||||||||
| BCVA | 0.99 ± 0.03 | 0.98 ± 0.04 | 0.68 ± 0.23 | 0.63 ± 0.23 | 0.317 | <0.001 | <0.001 | 0.040 | (−0.292) | 0.273 | (−0.424) | 0.102 |
| Age | 45.50 ± 11.28 | 45.50 ± 11.67 | 36.13 ± 10.46 | 37.00 ± 10.85 | 1.000 | 0.091 | 0.188 | 0.080 | 0.108 | 0.691 | 0.000 | 1.000 |
| IOP | 16.00 ± 1.89 | 15.31 ± 1.89 | 14.13 ± 2.75 | 14.00 ± 2.56 | 0.095 | 0.058 | 0.079 | 0.766 | 0.095 | 0.708 | 0.005 | 0.808 |
| SARA | 0.00 ± 0.00 | 0.00 ± 0.00 | 28.38 ± 3.54 | 29.38 ± 4.32 | 1.000 | <0.001 | <0.001 | 0.071 | ------ | ------ | ------ | ------ |
| VFI | 98.88 ± 1.59 | 99.13 ± 1.09 | 66.57 ± 34.61 | 70.50 ± 25.80 | 0.425 | 0.039 | 0.026 | 0.860 | (−0.564) | 0.035 | (−0.284) | 0.371 |
| MD | (−0.40) ± 1.67 | (−0.05) ± 1.09 | (−13.88) ± 10.67 | (−10.22) ± 9.21 | 0.353 | 0.005 | 0.006 | 0.233 | (−0.554) | 0.040 | (−0.272) | 0.392 |
| PSD | 1.61 ± 0.45 | 1.68 ± 0.62 | 4.13 ± 2.51 | 4.48 ± 3.14 | 0.494 | 0.005 | 0.034 | 0.308 | 0.188 | 0.520 | 0.201 | 0.532 |
| % FN | 0.94 ± 1.34 | 2.19 ± 3.04 | 14.86 ± 10.60 | 12.83 ± 14.08 | 0.054 | 0.002 | 0.107 | 0.959 | 0.270 | 0.351 | 0.029 | 0.929 |
| % FP | 3.49 ± 3.20 | 3.25 ± 4.07 | 6.36 ± 7.47 | 13.75 ± 14.91 | 0.846 | 0.299 | 0.123 | 0.035 | 0.173 | 0.554 | 0.253 | 0.428 |
* Lineal mixed model. Data are expressed as mean ± standard deviation (SD) (except gender). Numbers in bold p < 0.05 after Bonferroni correction. BCVA: best-corrected visual acuity; IOP: intraocular pressure. FRDA: Friedreich ataxia; SARA: Scale for the Assessment and Rating of Ataxia; parameters that measure retinal sensitivity: VFI: Visual Field Index; MD: mean deviation (dB); PSD: pattern standard deviation; parameters that measure visual field reliability: % FN: percentage of false-negative errors; % FP: percentage of false-positive errors.