Table 2.

Yields and preliminary cell viability data for compounds 16a–n (Series IIIA) in MUTU-1 and DG-75 Burkitt lymphoma cell lines.

			MUTU-1 Cell Viability %		DG-75 Cell Viability %
Compound	Substitution	Yield (%)	10 μM	1 μM	10 μM	1 μM
16a	R1=R2=R3=R4=R5=H	30	1.4	10.3	1.1	1.1
16b	R1=R2=R3=R5=H, R4=Cl	51	0.38	5.0	0.52	5.5
16c	R1=R2=R3=R5=H, R4=OCH3	70	1.1	0.19	2.1	28.4
16d	R1=Cl, R2=R3=R4=R5=H	15	0.41	0.77	5.1	13.5
16e	R1=R2=R3=R5=H, R4=F	27	1.4	0.07	2.3	35.4
16f	R1=R2=H, R3=R4=R5=OCH3	10	1.1	1.8	0.46	25.6
16g	R1=R2=R3=R5=H, R4=Br	66	1.1	2.1	0.55	28.2
16h	R1=R2=R3=R5=H, R4=(C=O)OCH3	60	0.79	2.3	0.18	20.8
16i	R1=R2=R3=R5=H, R4=(C=O)C6H5	40	1.2	2.0	2.7	77.5
16j	R1=R2=R4=H, R3=R5=OCH3	63	5.4	4.2	0.16	33.5
16k	R1=R2=R4=R5=H, R3=Cl	58	0.84	2.7	0	69.0
16l	R1=R3=R4=R5=H, R2=OH	40	0.61	2.3	0	59.2
16m	R1=R2=R4=R5=H, R3=O(C=O)CH3	50	1.2	2.0	0	35.9
16n	R1=R2=R3=R5=H, R4=NH2	45	3.7	1.7	0.18	20.8
Maprotiline 8	-	-	73.0	93.1	65.1	102.0
Taxol	-	-	9.8	30.4	9.9	48.8

Cell proliferation of MUTU-1 and DG-75 cells was determined with an alamarBlue assay (seeding density 1–5 × 10⁴ cells/mL per well for 96-well plates). Compound concentrations of either 1 μM or 10 μM for 24 h (MUTU-1) or 48 h (DG-75) were used to treat the cells (in triplicate) with control wells containing vehicle ethanol (1% v/v). The mean value for three experiments is shown.