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. 2020 Jan 17;13(1):16. doi: 10.3390/ph13010016

Table 8.

Yields and preliminary cell viability data for compounds 21a–k (Series VI) in MUTU-1 and DG-75 Burkitt lymphoma cell lines a.

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Compound R X Yield (%) MUTU-1 Cell Viability % DG-75 Cell Viability %
10 μM 1 μM 10 μM 1 μM
21a H O 90 93.1 103.2 69.9 91.4
21b H NH 85 92.8 104.1 74.5 82.0
21c H N(C6H5) 90 91.2 93.0 71.3 85.7
21d CHO O 40 88.4 87.4 64.7 64.8
21e CHO NH 35 95.1 96.1 71.2 76.0
21f CHO N(C6H5) 62 77.7 102.2 72.4 102.0
21g COOH O 81 88.8 99.2 65.4 93.1
21h COOH NH 41 92.0 92.6 73.1 86.3
21i COOH N(C6H5) 43 92.5 103.4 67.5 73.2
21j OH O 55 100.4 103.4 93.0 68.0
21k OH NH 58 100.1 104.0 80.9 65.9
Maprotiline 8 - - - 73.0 93.1 65.1 102.0
Taxol - - - 9.8 30.4 9.9 48.9

a Cell proliferation of MUTU-1 and DG-75 cells was determined with an alamarBlue assay (seeding density 1–5 × 104 cells/mL per well for 96-well plates). Compound concentrations of either 1 μM or 10 μM for 24 h (MUTU-1) or 48 h (DG-75) were used to treat the cells (in triplicate) with control wells containing vehicle ethanol (1% v/v). The mean value for three experiments is shown.