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. 2020 Jan 17;13(1):16. doi: 10.3390/ph13010016

Table 9.

Yields and preliminary cell viability data for compounds 23a–k (Series VII) in MUTU-1 and DG-75 Burkitt lymphoma cell lines a.

graphic file with name pharmaceuticals-13-00016-i014.jpg MUTU-1 Cell Viability % DG-75 Cell Viability %
Compound X Y R1 R2 R3 Yield (%) 10 μM 1 μM 10 μM 1 μM
23a O C H CN H 74 82.6 82.7 75.8 89.0
23b NH C H CN H 38 79.4 79.4 54.1 101.1
23c N(C6H5) C H CN H 20 74.1 90.7 89.1 94.4
23d O C H CN CN 15 82.7 99.8 95.7 103.1
23e NH C H CN CN 42 83.6 82.9 98.7 85.7
23f N(C6H5) C H CN CN 44 71.8 78.9 81.6 82.0
23g NH N H NH2 H 63 100.9 95.2 55.0 78.1
23h N(C6H5) N H NH2 H 54 78.0 91.1 87.4 85.8
23i NH N Cl NH2 H 34 106.2 102.1 18.9 85.8
23j NH N H OH H 43 87.6 92.8 63.9 69.1
23k N(C6H5) N H OH H 66 83.9 96.9 74.1 81.7
Maprotiline 8 - - - - - - 73.0 93.1 65.1 102.0
Taxol - - - - - - 9.8 30.4 9.9 48.8

a Cell proliferation of MUTU-1 and DG-75 cells was determined with an alamarBlue assay (seeding density 1–5 × 104 cells/mL per well for 96-well plates). Compound concentrations of either 1 μM or 10 μM for 24 h (MUTU-1) or 48 h (DG-75) were used to treat the cells (in triplicate) with control wells containing vehicle ethanol (1% v/v). The mean value for three experiments is shown.