Table 11.
IC50 values of selected compounds 12a, 13j, 15, 16a–d, 19a in BL cell lines DG-75 and MUTU-I Burkitt lymphoma cell lines.
| Compound | IC50 (µM) a | IC50 (µM) a | logP b |
|---|---|---|---|
| MUTU-I 24 h | DG-75 48 h | ||
| 12a | 2.57 | 2.08 | 4.763 |
| 13j | 0.25 | 0.78 | 3.310 |
| 15 | 0.09 | 0.24 | 5.060 |
| 16a | 0.21 | 0.71 | 4.616 |
| 16b | 0.17 | 0.45 | 5.269 |
| 16c | 0.20 | 0.56 | 4.625 |
| 16d | 0.22 | 0.59 | 4.960 |
| 19a | 0.38 | 0.69 | 4.275 |
| Taxol | 0.32 | 1.32 | 7.380 |
| Maprotiline 8 | 15.8 | 37.5 | 4.602 |
| |||
a Cell proliferation of MUTU-1 and DG-75 cells was determined with an alamarBlue assay (seeding density 1–5 × 104 cells/mL per well for 96-well plates). The compounds (concentration range 0.01 nM to 50 μM) were added (in triplicate) and the cells retained for 24 h (MUTU-1) or 48 h (DG-75), with control wells containing vehicle ethanol (1% v/v). The values represent the mean for three experiments. IC50 value is the concentration required for 50% growth inhibition of MUTU-1 cells. b log P values calculated from ChemDraw Ultra, version 12.0. (PerkinElmer, Waltham, MA, USA).