Table 3.

Dosage adjustment of oral oseltamivir, i.v. peramivir and i.v. zanamivir for adults with and without renal impairment58

	CrCl (mL/min)				Dialysis
Oseltamivir	>60 to 90	>30 to 60	>10 to 30	<10	CAPD/HD
	75 mg bd	30 mg bd	30 mg qd	Data limited; may consider single dose at 30 mg	CAPD: 30 mg single dose HD: 30 mg after every HD cycle
Peramivir	50 to 80	31 to 49	10 to 30	<10	HD
	600 mg qd	200 mg qd	100 mg qd	Data limited; may consider 100 mg on Day 1, then 15 mg qd thereafter	100 mg on Day 1, then 100 mg given 2 h after each HD session on dialysis days only
Zanamivir	50 to <80	30 to <50	15 to <30	<15	—
Initial dose 600 mg; maintenance dose for CrCl > 80 mL/min is 600 mg bd†	400 mg bd	250 mg bd	150 mg bd	60 mg bd	—

^† Time interval between initial dose of zanamivir and the maintenance dose in patients with CrCl > 80 mL/min = 12 h; CrCl 15 to <30 = 24 h; CrCl <15 mL/min = 48 h.

CAPD, continuous ambulatory peritoneal dialysis; CrCl, creatinine clearance; HD, haemodialysis; qd, once a day.