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. 2016 Jul 4;26(6):389–407. doi: 10.1002/rmv.1894

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Copyright © 2016 John Wiley & Sons, Ltd.

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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Adenovirus encodes viral miRNAs (miVARNAs) that potently inhibit human pre‐microRNA (miRNA) via inhibition the nuclear export of pre‐miRNA, competition for the exportin 5, and inhibition of Dicer activity by direct binding of Dicer. The miVARNAs are able to target cellular and viral genes that are important for virus cell cycle. Adenovirus miVARNAs target cellular genes involved in cell proliferation, DNA repairing, and RNA regulation. However, cellular miRNAs may play a role in anti‐adenovirus replication by regulating virus gene expression.