Table I.

Data Sets on Dose‐Response Relationship for Coronavirus Infection via Intranasal Route*

No.	Virus	Genetic Group	Host		Reported Symptom	Number of Doses	Endpoint of Response	Reference
			Animal	Age
1	rSARS‐CoV**	2	tgMicet†	?	R,CNS	4 (1††)	Death	11
2	MHV‐1	2	Mice	6 to 8 weeks	R	4(2)	Death	9
3	HCoV‐229E	1	Humans	18 to 50 years	R	4(4)	Illness (Cold)	12
4	MHV‐S	2	Mice	3 days	CNS,H	4(1)	Death	13
5	MHV‐S	2	Mice	1 week	CNS,H	4(1)	Death	13
6	MHV‐S	2	Mice	2 weeks	CNS,H	4(1)	Death	13
7	MHV‐2	2	Mice	3 weeks	H	3(0)	Death	14
8	MHV‐2	2	Mice	4 weeks	H	3(0)	Death	14
9	HEV‐67N	2	Mice	1 week	CNS	4(1)	Death	15
10	HEV‐67N	2	Mice	4 weeks	CNS	5(1)	Death	15
11	HEV‐67N	2	Mice	8 weeks	CNS	5(1)	Death	15
12	HEV‐67N	2	Rats	1 week	CNS	4(1)	Death	16
13	HEV‐67N	2	Rats	4 weeks	CNS	3(1)	Death	16
14	HEV‐67N	2	Rats	8 weeks	CNS	3(2)	Death	16
15	IBVA‐5968	3	Chicks	9 weeks	R,K	6(4)	Death	17

R = respiratory; CNS = central nervous system; H = hepatitis; K = kidney damage.

*Only data set 15 was obtained by intratracheal inoculation.

**Recombinant SARS‐CoV.

^†Transgenic mice expressing the SARS‐CoV receptor.

^††Number of dose points corresponding to other than 0 or 100% response.