. 2004 Jul 16;87(1):10–18. doi: 10.1111/j.1423-0410.2004.00530.x

Table 3.

Virus inactivation by tri‐(n‐butyl)‐phosphate (TNBP)/Tween 80 in solutions of anti‐haemophilic factor (AHF) or TNBP/cholate in intravenous immunoglobulin produced using the solvent/detergent process (IVIG‐S/D)

Protein	Inactivation step	Log₁₀ inactivation
Protein	Inactivation step	WNV	BVDV	VV
AHF	0·3% TNBP/1% Tween 80	5·9 ^a	5·3	3·0 ^b
AHF	0·15% TNBP/0·5% Tween 80	5·9 ^a	5·2	ND ^c
IVIG‐S/D	0·3% TNBP/0·2% Cholate	5·9 ^d	4·2	4·6 ^e
IVIG‐S/D	0·15% TNBP/0·1% Cholate	6·2 ^d	3·9	ND

^{^a}

From Fig. 1(a).

^{^b}

From Fig. 1(b).

^{^c}

ND = not determined.

^{^d}

From Fig. 1(c).

^{^e}

From Fig. 1(d).

For West Nile virus (WNV), each value represents the mean of three determinations; for bovine viral diarrhoea virus (BVDV), each value represents the mean of two or three determinations; and for vaccinia virus (VV), the value is the result of a single determination.

Solvent/detergent solutions were incubated at 28 °C for 6 h.