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ZeOncoTest pipeline. Fluorescently labeled cells are injected in 48 hpf larvae, subsequently imaged at tp1. After the first imaging, xenotransplanted larvae are incubated at 35 °C with the NOEC of candidate drugs, previously calculated. Subsequent imaging is performed at tp2. The evaluation of drug impact on tumor growth and metastatic potential is given by the calculation and comparison of tumor mass and dispersion of cells at the 2 time points, in treated and untreated animals.
