Figure 7.

Effect of TRX under cyclooxygenase-2 pathway (COX-2) evaluated by histopathological and morphometric analysis in segments of the duodenum. The tissues were submitted to H&E staining for morphometric and histopathological analysis after incubation with celecoxib. Salina (A); 5-FU (B); TRX-100 (C); CLX (D); TRX and CLX (E); height of villi (F); depth of the crypts (G); villus/crypt ratio (H). The histopathological issues are indicated by arrows. Inflammatory cells infiltration (red arrow), decreasing of intestinal villi (black arrow) and loss of intestinal crypt architecture (blue arrow). Values were expressed as mean ± SEM. For statistical analysis, one-way ANOVA followed by the Tukey test was used, where p < 0.05 vs. saline group, * p < 0.05 vs. 5-FU group, ** p < 0.05 vs. TRX group.