Table 1.
Clinical data and immunohistochemical profile of six atypical angiofibroma/angiofibroma with sarcomatous transformation and two cellular angiofibroma control cases.
| Case No. | Gender | Age | Location | Size (cm) | Depth | Atypical Areas | 50/HPF | Atypical MF | Necrosis (%) | Infiltration | ER/PR | CD34 | p16 | p53 | RB1 FISH | Follow-up |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | F | 68 | pelvis | 4 | deep | CAS with PLPS-like areas | 2 | no | 0 | circumscribed | 1+ | 3+ | 3+ | negative | positive | 16 months |
| 2 | M | 36 | hip | 9 | deep | CAS with UPS-like areas | 8 | no | 0 | mixed | 1+ | 3+ | 3+ | positive | positive | 12 months |
| 3 | M | 73 | inguinal | 3.5 | superficial | CAS with PLPS-like areas | 0 | no | 0 | circumscribed | 3+ | 3+ | 2+ | negative | positive | 10 months |
| 4 | F | 48 | perineum | 2.3 | superficial | CAS with UPS-like areas | 4 | no | 0 | circumscribed | 3+ | 3+ | 2+ | negative | positive | 12 months |
| 5 | F | 25 | vulva | 4.3 | deep | ACA | 0 | no | 0 | circumscribed | 3+ | 1+ | 2+ | negative | positive | 8 months |
| 6 | F | 43 | vulva | 7 | deep | CAS with PLPS-like areas | 6 | no | 0 | circumscribed | 3+ | 3+ | 2+ | positive | positive | 6 months |
| CA1 | M | 63 | inguinal | 7.5 | deep | 2 | no | 0 | circumscribed | 1+ | 2+ | negative | negative | positive | 12 months | |
| CA2 | F | 52 | vulva | 2.2 | superficial | 0 | no | 0 | circumscribed | 1+ | 2+ | negative | negative | positive | 24 months |
Bold letters represent the p53 positive cases. CA: cellular angiofibroma, ACA: atypical angiofibroma, CAS: angiofibroma with sarcomatous transformation, PLPS: pleomorphic liposarcoma, UPS: undifferentiated pleomorphic sarcoma, ER/PR: xxx, FISH: fluorescence in situ hybridization; 1+, 2+, and 3+ indicate mild, moderate, and strong positivity by immunohistochemical stain.