Table 2.

Summary of chelators for the different radioactive isotopes and published labelling conditions (reaction temperature and incubation time).

Isotope	Chelator	Labelling Conditions	Reference
[64Cu]	CB-TE2A a	95 °C, 1 h	[113]
	CB-TE2P	RT	[80]
	DOTA b	RT, 15 min	[114]
	NOTA c	RT, 45 min	[115]
	PCB-TE2A	RT	[75]
	TETA d	RT, 45 min	[74]
	Sarcophagine-based chelators	RT, within min	[75,82]
[68Ga]	AAZTA e	RT, 10 min	[116]
	DFO f	RT, 5 min	[116]
	DOTA b	95 °C, 5 min	[116]
	DTPA g	RT, 10 min	[117]
	HBED-CC h	80–100 °C, 5–20 min	[85]
	NODAGA i	RT, 10 min	[86]
	NOTA c	RT, 10 min	[118]
	TRAPj/NOPO k	95–100 °C, 5 min; RT or 95 °C, 5 min	[87,89]
[89Zr]	DFO f	RT, 30 min	[119]
	DOTA b	95 °C, 60 min	[97]
	FSC l	RT, 90 min	[120]
[90Y]	3p-C-NETA-NCS m	RT, 60 min	[106]
	CHX-A’’-DTPA n	37–75 °C, 30–60 min	[82]
	DOTA b	80 °C, 20 min	[121]
[177Lu]	3p-C-NETA-NCS m	RT, 60 min	[106]
	AAZTA-5	RT, 10 min	[104]
	DOTA b	80 °C, 20 min	[121]
	H4octapa o	RT, 15 min	[105]
[224Ac]	DOTA b	95 °C, 5 min	[109]
	H2macropa p	RT, within several min	[112]
	HEHA q	37 °C, 30 min	[122]

^a 4,11-bis(carboxymethyl)-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane, ^b 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid, ^c 1,4,7-triazacyclononane-1,4,7-triacetic acid, ^d 1,4,8,11-tetraazacyclotetradecane-1,4,8,11-tetraacetic acid, ^e 1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine, ^f desferrioxamine B, ^g diethylenetriamine pentaacetic acid, ^h N,N′-bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N′-diacetic acid, ⁱ 1,4,7-triazacyclononane,1-gluteric acid-4,7-acetic acid, ^j 1,4,7-triazacyclononane phosphinic acid, ^k 1,4,7-triazacyclononane-1,4-bis[methylene(hydroxymethyl)phosphinic acid]-7-[methylene(2-carboxyethyl) phosphinic acid], ^l fusarinine C, ^m {4-[2-(Bis-carboxy-methylamino)-5-(4-isothiocyanatophenyl) pentyl]-7-carboxymethyl[1,4,7] triazonan-1-yl}acetic acid, ⁿ 2-(p-isothiocyanatobenzyl)-cyclohexyldiethylenetriamine pentaacetic acid, ^o N,N′-bis(6-carboxy-2-pyridylmethyl)-ethylenediamine-N,N′-diacetic acid), ^p N,N’-bis[(6-carboxy-2-pyridil)methyl]-4,13-diaza-18-crown-6, ^q 1,4,7,10,13,16-hexaazacyclohexadecane-N,N′,N″,N‴,N′‴,N″‴-hexaacetic acid.