Table 2. Summary of Adverse Events.

Event	Invasive Ventilation (N=34)	Noninvasive Oxygen Support (N=19)	Total (N=53)
	number of patients (percent)
Any adverse event	22 (65)	10 (53)	32 (60)
Adverse events occurring in 2 or more patients
Hepatic enzyme increased*	8 (24)	4 (21)	12 (23)
Diarrhea	1 (3)	4 (21)	5 (9)
Rash	3 (9)	1 (5)	4 (8)
Renal impairment	4 (12)	0	4 (8)
Hypotension	3 (9)	1 (5)	4 (8)
Acute kidney injury	2 (6)	1 (5)	3 (6)
Atrial fibrillation	2 (6)	1 (5)	3 (6)
Multiple-organ-dysfunction syndrome	3 (9)	0	3 (6)
Hypernatremia	3 (9)	0	3 (6)
Deep-vein thrombosis	3 (9)	0	3 (6)
Acute respiratory distress syndrome	1 (3)	1 (5)	2 (4)
Pneumothorax	2 (6)	0	2 (4)
Hematuria	2 (6)	0	2 (4)
Delirium	1 (3)	1 (5)	2 (4)
Septic shock	2 (6)	0	2 (4)
Pyrexia	1 (3)	1 (5)	2 (4)
Any serious adverse event	9 (26)	3 (16)	12 (23)
Serious events occurring in 2 or more patients
Multiple-organ-dysfunction syndrome	2 (6)	0	2 (4)
Septic shock	2 (6)	0	2 (4)
Acute kidney injury	2 (6)	0	2 (4)
Hypotension	2 (6)	0	2 (4)

^*Adverse-event terms are based on the Medical Dictionary for Regulatory Activities, version 22.1. Hepatic enzyme increased includes the following terms: hepatic enzyme increased, alanine aminotransferase increased, aspartate aminotransferase increased, and transaminases increased. Elevated hepatic enzymes resulted in discontinuation of remdesivir therapy in 2 patients.