Table 2.
Details of polymorphism, P‐values and OR, cancer risk association, population type and case studies with references.
| Polymorphism | Disease associations/No associations (cancer risk) | P‐values and OR | Population | Cases and controls (n) | References |
|---|---|---|---|---|---|
| rs1800630, rs361525 | No association with breast cancer | OR = 0.82 [0.64–1.04], P = 0.637 | North European | 709 patients and 498 controls | Azmy et al. [65] |
| rs361525 | Evidence against an overall association between invasive breast cancer risk and TNF rs361525 | OR 1.00 (0.95–1.06) | Europe, USA and Australia | 30,000 cases and 30,000 controls | Gaudet et al. [66] |
| 10 SNPs | Genotype distribution of 3 SNPs differed significantly between case subjects and 1 or both of the control groups | <0.05 | New Mexico | 341 cases and 241 controls | Deshpande et al. [68] |
| rs1799724, rs1800610 | Significant association with prostate cancer risk | Significant | Nutrition Cohort | 2321 cases and 2560 controls | Danforth et al. [69] |
| rs1800629 | No overall association between pancreatic cancer risk and TNF‐α (rs1800629 G/A) | Pancreatitis significantly associated with rs1800629 GA + AA (OR, 3.1; 95% CI, 1.3–7.4) | San Francisco Bay Area | 532 cases and 1701 controls | Duell et al. [71] |
| rs1800630, rs361525 | rs1800630, rs361525 were significantly different between the patients with lung cancer and controls | 0.0001 | Taiwan | Patients 202, controls 205 | Shih et al. [72] |
| rs1800629 | rs1800629 G‐allele significantly higher in RCC patients compared to controls | Significant | Turkey | 29 patients, 50 controls | Baştürk et al. [73] |
| rs1800629 | rs1800629 was significantly associated with the risk of HCC | <0.001, odds ratio [OR] = 4.75 | Turkish | 110 patients and 110 control | Akkiz et al. [75] |
| rs1800629, rs361525 | Both SNPs of TNF‐α are not genetic risk factor for AP susceptibility | OR = 1.63; 1.13−4.01 for rs1800629 and OR = 0.86; 0.75−1.77 for rs361525 | Turkey | 103 patients with acute pancreatitis (AP) and 92 controls | Ozhan et al. [76] |
| rs1800629, rs1143627, rs1800896, rs361525 | rs1800629 confer a higher risk of HCC. Other polymorphisms were not related to risk of HCC in this study | OR = 1.74 | 20 studies Caucasian and Asian | 2763 patients with HCC and 4152 controls | Yang et al. [166] |
RCC, renal cell carcinoma; HCC, hepatic cell carcinoma; AP, acute pancreatitis; TNF‐α, tumor necrosis factor‐alpha.