Table 3.

 Details of polymorphism, other disease association, P‐values and OR, population type and case studies with references.

Polymorphism	Disease associations/No associations (others)	P‐values and OR	Population	Cases and controls (n)	References
TNF, IFNA10, IFNA17, IFNG genes	A statistically significant increase of CFTR mutation carriers in the population of patients with sarcoidosis versus the control population was found	6.1 × 10−8	Greek	89 Greek patients with sarcoidosis and 212 control	Makrythanasis et al. [77]
rs1799724	Significant increase in rs1799724 CC genotype in ms. The rs1800629 and rs361525 Not associated with MS	<0.001	Turkish	86 patients and 150 controls	Akcali et al. [78]
rs1799964, rs1799724, rs1800750	Haplotype rs1799964 T/rs1800630 C/rs1799724 C/rs1800629 G increased the risk of susceptibility to AS compared to random controls	P (corr) < 0.001, OR = 2.756	China	119 patients,95 healthy controls, and 135 random healthy controls	Chung et al. [84]
rs1800629, rs361525, rs3093661	G‐alleles of rs361525 and rs3093661 SNPs have been associated with higher risk of Graves’ disease as compared with A‐alleles. No significant difference of rs1800629 allelic frequency	OR = 2.385	Chinese	436 patients and 316 control subjects	Gu et al. [86]
rs1800629	rs1800629 A‐allele is associated with overall susceptibility to asthma	OR = 1.37, P = 0.04	China	2409 patients and 3266 controls	Gao et al. [118]
rs1800629	A‐allele increases the production of TNF‐α. TNF2A allele frequency was elevated in patients with PBC	OR = 1.21, P = 0.042	US and Canada	866 patients with PBC and 761 controls	Juran et al. [119]
rs1799964	rs1799964 associated with bowel disease	0.00004	UK white Caucasoid	133 patients with IBD and 354 healthy controls	Ahamad et al. [174]
rs1800629	rs1800629 and an atopic history impact the severity of irritation		USA	68 healthcare workers with irritant hand dermatitis	Davis et al. [121]
rs1800629, rs361525	Significantly increased risk was associated with the variant GA + AA genotypes of rs361525, compared with the GG genotype and significantly reduced psoriasis risk was associated with the variant GA + AA genotypes of the rs1800629, compared with the GG genotype	OR = 2.60	Various ethnicities	997 cases, 943 control for rs361525 and 1156 cases, 1083 control for rs1800629	Li et al. [122]
rs1800630, rs1800629	Association between TNF haplotype and plasma levels of plasminogen activator factor inhibitor 1 (PAI‐1)	Significant	Swedish	1209 subjects with MI	Mellick [62]
rs1800629	Cardiovascular risk factors did not differ between TNF‐alpha rs1800629 high‐/low‐producer genotype groups		Turkish	102 non‐diabetic patients	Yilmaz et al. [124]
rs1800630, rs1800629, rs1799964	SDICH risks were positively associated with the minor alleles rs1799964 C and – rs1800629 A in men but inversely associated with rs1800630 A in females (P = 0.03)	P = 0.03 and P = 0.005, respectively	Taiwan	260 SDICH patients and 368 controls	Chen et al. [125]
rs1800629, rs361525	Association with homocysteine levels in patients with ischemic strokes and silent brain infarctions	<0.05	Koreans	257 patients with SBIs, and 216 control	Kim et al. [127]
rs1800629	A significantly increased risk of SAD was observed in the carriers of A‐allele	OR = 2.635, P < 0.01	Southern China	112 patients and 121 controls	Yang et al. [129]
rs1800630, rs1800629, rs1799964	No significant difference in genotype distribution of rs1800629 in AD was found and no association for rs1800630 and rs1799964. A significant association between −850 polymorphism and AD risk	TT vs. TC + CC: pooled odds ratio [OR], 1.61; 1.08–2.29; P = 0.02	Caucasian Australians and Northern Europeans	Meta analysis	Di Bona et al. [130]
Promoter SNPs	No positive associations were found with AD		Italian cohort	253 patients with AD and 356 controls	Tedde et al. [131]
rs1800629	Carriers of the A‐allele demonstrated better attentional processes as compared to G‐allele carriers. The distribution of rs1800629 genotypes did not significantly differ from the Hardy–Weinberg equilibrium	0.202	Caucasian	67 genetically unrelated healthy participants	Beste et al. [136]
rs1800629	rs1800629 A‐allele was associated with worsened labile anger	<0.05	USA	105 patients with hepatitis C	Lotrich et al. [137]
rs361525	Associated with increased risk of new ICH	0.003	Northern California	280 patients	Achrol et al. [139]
rs1799964	Variability of the rs1799964 polymorphism may be associated with susceptibility to endometriosis. The frequency of the rs1799964 C allele was significantly lower in stage IV endometriosis cases than controls	P = 0.04; OR = 1.75, 1.019–3.01	Japanese	185 female neonates born at the Hayashi Clinic in Kobe, Japan	Asghar et al. [5]
rs1799964, rs180063, rs1799724, rs1800629, rs361525	Alleles −1031 and −863, individually or in combination in the haplotype −1031C −863A −857C −308G 238G, were associated with lower muscle mass in men. Specifically, carriers of −1031C, compared with non‐carriers, exhibited lower arm muscle mass	0.01	European descent	1050. Most participants are of European descent	Liu et al. [141]
rs361525, rs1800629	No association with Paget’s disease of bone	ns	Spanish patients	172 patients and 150 healthy controls	Corral‐Gudino et al. [142]
rs2229094 of LTA	Strong association between rs2229094 and development of Proliferative Vitreoretinopathy	0.0283	Spain	450 patients and 312 controls	Rojas et al. [143]
rs1800629, rs361525, rs909253	The rs361525 and rs909253 but not rs1800629, polymorphic variants are associated with early RM. Haplotype rs1800629 G/rs361525 A/rs909253 G show association with RM	Confirmed by regression analysis	Tunisia	372 RM women and 274 age‐matched parous control women	Zammiti et al. [145]

SAD, sporadic Alzheimer’s disease; ICH, intracranial haemorrhage; MS, multiple sclerosis; PBC, primary biliary cirrhosis; AD, Alzheimer’s disease; SDICH, spontaneous deep intracerebral hemorrhage; RM, recurrent miscarriage; CFTR, cystic fibrosis conductance regulator; ns, non‐significant; AS, ankylosing spondylitis; IBD, inflammatory bowel disease; MI, myocardial infarction; TNF, tumor necrosis factor.