. 2016 Jan 8;7(2):213–226. doi: 10.1002/wrna.1326

Table 1.

Host Cellular Proteins Interact with Viral NCs

Virus	Host Cellular Proteins	Function in Viral Life Cycle	References
Coronaviruses	GSK3	Template switching from discontinuous to continuous transcription	7, 8, 16
Coronaviruses	DDX1	Production of longer sgmRNAs and gRNAs	7, 8, 16
Hantavirus	eIF4G	Ensure the efficient translation of viral mRNAs	19
	eIF4A	Ensure the efficient translation of viral mRNAs	19
	Ribosomal protein 19	Help host translation machinery preferentially bind to the viral transcripts	20, 21
RSV	eEF1A	Facilitate gRNA synthesis and virus production	22
TMV			23, 24
TBSV			25, 26
PRRSV	Poly [ADP–ribose] polymerase 1	Increases the propagation of PRRSV	28, 29
PRRSV	Poly (A)‐binding protein	Enhance viral replication	28, 29
HCV	AP2M1	Essential for vial assembly	30, 31, 32, 33, 34
	DGAT1	Recruit core protein to lipid	35
	MAPKAPK3	Essential for HCV propagation	36
	Human myeloid cell factor 1	Proapoptotic property	71
PEDV	TBK1	Inhibits IFN‐β production	10
LCMV	IKKε	Inhibits IFN‐β production	69

DGAT1, diacylglycerol acyltransferase 1; GSK3, glycogen synthase kinase‐3; HCV, hepatitis C virus; IKKε, IκB kinase‐related kinase; MAPKAPK3, mitogen‐activated protein kinase‐activated protein kinase 3; NCs, nucleocapsid proteins; PRRSV, Porcine reproductive and respiratory syndrome virus; RSV, respiratory syncytial virus; TBK1, TANK‐binding kinase 1; TBSV, tomato bushy stunt virus; TMV, Tobacco mosaic virus.