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No‐go decay (NGD) as an antiviral pathway. In yeast ectopically expressing the plant protein PAP, the RNAs of Brome mosaic virus are depurinated. This causes translating ribosomes to stall, thereby triggering NGD via recruitment of the endonuclease Dom34p to the translation complex. After Dom34p cleaves the RNA close to the site of stalling, the resulting fragments become targets for exonucleases such as Xrn1 and the exosome.
