Table 1.
Biological agents and toxins (US and UK Governments)
| US (National Select Agent Registry 2012) | UK (HMSO 2001) |
|---|---|
|
US Department of Health and Human Services (HHS) select agents and toxins Abrin Botulinum neurotoxinsa Botulinum neurotoxin producing species of Clostridium a Conotoxins (Short, paralytic alpha conotoxins containing the following amino acid sequence X1CCX2PACGX3X4X5X6CX7) Coxiella burnetii Crimean‐Congo haemorrhagic fever virus Diacetoxyscirpenol Eastern equine encephalitis virusb Ebola virusa Francisella tularensis a Lassa fever virus Lujo virus Marburg virusa Monkeypox virusb Reconstructed replication competent forms of the 1918 pandemic influenza virus containing any portion of the coding regions of all eight gene segments (Reconstructed 1918 Influenza virus) Ricin Rickettsia prowazekii SARS‐associated coronavirus (SARS‐CoV) Saxitoxin South American Haemorrhagic Fever viruses: Chapare Guanarito Junin Machupo Sabia Staphylococcal enterotoxins A, B, C, D, E subtypes T‐2 toxin Tetrodotoxin Tick‐borne encephalitis complex (flavi) viruses: Far Eastern subtype Siberian subtype Kyasanur Forest disease virus Omsk haemorrhagic fever virus Variola major virus (Smallpox virus)a Variola minor virus (Alastrim)a Yersinia pestis a |
Chikungunya virus Congo‐crimean haemorrhagic fever virus Dengue fever virus Dobrava/Belgrade virus Eastern equine encephalitis virus Ebola virus Everglades virus Getah virus Guanarito virus Hantaan virus Hendra virus (Equine morbillivirus) Herpes simiae (B virus) Influenza viruses (pandemic strains) Japanese encephalitis virus Junin virus Kyasanur Forest virus Lassa fever virus Louping ill virus Lymphocytic choriomeningitis virus Machupo virus Marburg virus Mayaro virus Middleburg virus Mobala virus Monkey pox virus Mucambo virus Murray Valley encephalitis virus Ndumu virus Nipah virus Omsk haemorrhagic fever virus Polio virus Powassan virus Rabies virus Rift Valley fever virus Rocio virus Sabia virus Sagiyama virus Sin Nombre virus St Louis encephalitis virus Tick‐borne encephalitis virus (Russian Spring–Summer encephalitis virus) |
|
Overlap select agents and toxins Bacillus anthracis a Bacillus anthracis Pasteur strain Brucella abortus Brucella melitensis Brucella suis Burkholderia mallei a Burkholderia pseudomallei a Hendra virus Nipah virus Rift Valley fever virus Venezuelan equine encephalitis virusb US Department of Agriculture (USDA) select agents and toxins African horse sickness virus African swine fever virus Avian influenza virusb Classical swine fever virus Foot‐and‐mouth disease virusa Goat pox virus Lumpy skin disease virus Mycoplasma capricolum b Mycoplasma mycoides b Peste des petits ruminants virus Rinderpest virusa Sheep pox virus Swine vesicular disease virus USDA Plant Protection and Quarantine (PPQ) select agents and toxins Peronosclerospora philippinensis (Peronosclerospora sacchari) Phoma glycinicola (formerly Pyrenochaeta glycines) Ralstonia solanacearum Rathayibacter toxicus Sclerophthora rayssiae Synchytrium endobioticum Xanthomonas oryzae |
Variola virus Venezuelan equine encephalitis virus Western equine encephalitis virus West Nile fever virus Yellow fever virus |
Denotes Tier 1 Agent.
Select agents that meet any of the following criteria are excluded from the requirements of this part: Any low pathogenic strains of avian influenza virus, South American genotype of eastern equine encephalitis virus, West African clade of Monkeypox viruses, any strain of Newcastle disease virus which does not meet the criteria for virulent Newcastle disease virus, all subspecies Mycoplasma capricolum except subspecies capripneumoniae (contagious caprine pleuropneumonia), all subspecies Mycoplasma mycoides except subspecies mycoides small colony (Mmm SC) (contagious bovine pleuropneumonia), any subtypes of Venezuelan equine encephalitis virus except for subtypes IAB or IC and vesicular stomatitis virus (exotic): Indiana subtypes VSV‐IN2, VSV‐IN3, provided that the individual or entity can verify that the agent is within the exclusion category.
A virulent Newcastle disease virus (avian paramyxovirus serotype 1) has an intracerebral pathogenicity index in day‐old chicks (Gallus gallus) of 0.7 or greater or has an amino acid sequence at the fusion (F) protein cleavage site that is consistent with virulent strains of Newcastle disease virus. A failure to detect a cleavage site that is consistent with virulent strains does not confirm the absence of a virulent virus.
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